Topology of Transmembrane Channel-like Gene 1 Protein
نویسندگان
چکیده
منابع مشابه
Transmembrane topology of a CLC chloride channel.
CLC chloride channels form a large and conserved gene family unrelated to other channel proteins. Knowledge of the transmembrane topology of these channels is important for understanding the effects of mutations found in human myotonia and inherited hypercalciuric kidney stone diseases and for the interpretation of structure-function studies. We now systematically study the topology of human Cl...
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Drosophila larval locomotion, which entails rhythmic body contractions, is controlled by sensory feedback from proprioceptors. The molecular mechanisms mediating this feedback are little understood. By using genetic knock-in and immunostaining, we found that the Drosophila melanogaster transmembrane channel-like (tmc) gene is expressed in the larval class I and class II dendritic arborization (...
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Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by increased sensitivity to infection by the β-subtype of human papillomaviruses (β-HPVs), causing persistent, tinea versicolor-like dermal lesions. In a majority of affected individuals, these macular lesions progress to invasive cutaneous squamous cell carcinoma (CSCC) in sun-exposed areas. While mutations in transmem...
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Transmembrane (TM) proteins (TMPs) have important roles in the biological organisms [1, 2]. With the rapid increasing of the number of TMPs, a lot of efforts are made in attempt to classify TMP functions by sequence analysis, and in fact, some databases aimed for it have been constructed (e.g., Pfam [3]). Which characteristics of TMP could provide us important clues to its function? We suppose ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2010
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi1004377